Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Ligand
BDBM50136908
Substrate
n/a
Meas. Tech.
ChEMBL_103130 (CHEMBL712301)
Ki
191±n/a nM
Citation
 Li, XChu, SFeher, VAKhalili, MNie, ZMargosiak, SNikulin, VLevin, JSprankle, KGTedder, MEAlmassy, RAppelt, KYager, KM Structure-based design, synthesis, and antimicrobial activity of indazole-derived SAH/MTA nucleosidase inhibitors. J Med Chem 46:5663-73 (2003) [PubMed]  Article 
Target
Name:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:
5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA
Type:
Enzyme
Mol. Mass.:
24347.14
Organism:
Escherichia coli (strain K12)
Description:
P0AF12
Residue:
232
Sequence:
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
  
Inhibitor
Name:
BDBM50136908
Synonyms:
CHEMBL153820 | N-(7-Isobutylamino-3-methyl-1H-indazol-5-yl)-3-(2-methyl-pyrimidin-4-yl)-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H26N6O2S
Mol. Mass.:
450.557
SMILES:
CC(C)CNc1cc(NS(=O)(=O)c2cccc(c2)-c2ccnc(C)n2)cc2c(C)n[nH]c12
Structure:
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