Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50125832
Substrate
n/a
Meas. Tech.
ChEBML_163993
IC50
>50000±n/a nM
Citation
Summa, V; Petrocchi, A; Pace, P; Matassa, VG; De Francesco, R; Altamura, S; Tomei, L; Koch, U; Neuner, P Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase. J Med Chem 47:14-7 (2003) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50125832
Synonyms:
(Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester | 2-Hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester | CHEMBL16633 | CHEMBL177429 | CHEMBL456227
Type:
Small organic molecule
Emp. Form.:
C11H10O4
Mol. Mass.:
206.1947
SMILES:
COC(=O)C(=O)CC(=O)c1ccccc1