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Target
Histone deacetylase 2b
Ligand
BDBM50135752
Substrate
n/a
Meas. Tech.
ChEMBL_87717 (CHEMBL857174)
IC50
100±n/a nM
Citation
 Mai, A; Massa, S; Cerbara, I; Valente, S; Ragno, R; Bottoni, P; Scatena, R; Loidl, P; Brosch, G 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. J Med Chem 47:1098-109 (2004) [PubMed]  Article 
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50135752
Synonyms:
(2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide | (E)-N-Hydroxy-3-(1-methyl-4-phenylacetyl-1H-pyrrol-2-yl)-acrylamide | CHEMBL12760 | N-Hydroxy-3-((E)-1-methyl-4-phenylacetyl-1H-pyrrol-2-yl)-acrylamide | N-Hydroxy-3-(1-methyl-4-phenylacetyl-1H-pyrrol-2-yl)-acrylamide
Type:
Small organic molecule
Emp. Form.:
C16H16N2O3
Mol. Mass.:
284.3098
SMILES:
Cn1cc(cc1C=CC(=O)NO)C(=O)Cc1ccccc1 |w:7.8|
Structure:
Search PDB for entries with ligand similarity: