Reaction Details Report a problem with these data
Target
Histone deacetylase 2b
Ligand
BDBM50139947
Substrate
n/a
Meas. Tech.
ChEMBL_87549 (CHEMBL695147)
IC50
130±n/a nM
Citation
 Mai, A; Massa, S; Cerbara, I; Valente, S; Ragno, R; Bottoni, P; Scatena, R; Loidl, P; Brosch, G 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. J Med Chem 47:1098-109 (2004) [PubMed]  Article 
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50139947
Synonyms:
CHEMBL265077 | N-Hydroxy-3-[1-methyl-4-(4-phenyl-butyryl)-1H-pyrrol-2-yl]-acrylamide
Type:
Small organic molecule
Emp. Form.:
C18H20N2O3
Mol. Mass.:
312.363
SMILES:
Cn1cc(cc1C=CC(=O)NO)C(=O)CCCc1ccccc1 |w:7.8|
Structure:
Search PDB for entries with ligand similarity: