Reaction Details Report a problem with these data
Target
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Ligand
BDBM50141297
Substrate
n/a
Meas. Tech.
ChEBML_100169
IC50
50±n/a nM
Citation
 Gong, B; Hong, F; Kohm, C; Bonham, L; Klein, P Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase-beta. Bioorg Med Chem Lett 14:1455-9 (2004) [PubMed]  Article 
Target
Name:
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Synonyms:
1-acylglycerol-3-phosphate O-acyltransferase beta | AGPAT2 | PLCB_HUMAN
Type:
PROTEIN
Mol. Mass.:
30924.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321473
Residue:
278
Sequence:
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
  
Inhibitor
Name:
BDBM50141297
Synonyms:
CHEMBL35564 | N-[4-Chloro-3-(5-trifluoromethyl-benzothiazol-2-yl)-phenyl]-2-cyano-acetamide
Type:
Small organic molecule
Emp. Form.:
C17H9ClF3N3OS
Mol. Mass.:
395.786
SMILES:
FC(F)(F)c1ccc2sc(nc2c1)-c1cc(NC(=O)CC#N)ccc1Cl
Structure:
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