Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50147858
Substrate
n/a
Meas. Tech.
ChEMBL_29112 (CHEMBL638724)
Ki
0.56±n/a nM
Citation
 Ferrarini, PL; Betti, L; Cavallini, T; Giannaccini, G; Lucacchini, A; Manera, C; Martinelli, A; Ortore, G; Saccomanni, G; Tuccinardi, T Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives. J Med Chem 47:3019-31 (2004) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36602.99
Organism:
BOVINE
Description:
ADENOSINE 0 BOVINE::P28190
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTPRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYMVYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPVDEDAPAERPDD
  
Inhibitor
Name:
BDBM50147858
Synonyms:
7-(dimethylamino)-2-phenyl-1,8-naphthyridin-4-ol | 7-Dimethylamino-2-phenyl-[1,8]naphthyridin-4-ol | CHEMBL102429
Type:
Small organic molecule
Emp. Form.:
C16H15N3O
Mol. Mass.:
265.3098
SMILES:
CN(C)c1ccc2c(O)cc(nc2n1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: