Reaction Details Report a problem with these data
Target
Melatonin receptor type 1A
Ligand
BDBM50149181
Substrate
n/a
Meas. Tech.
ChEBML_104948
Ki
0.630000±n/a nM
Citation
 Sun, LQ; Chen, J; Bruce, M; Deskus, JA; Epperson, JR; Takaki, K; Johnson, G; Iben, L; Mahle, CD; Ryan, E; Xu, C Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists. Bioorg Med Chem Lett 14:3799-802 (2004) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50149181
Synonyms:
CHEMBL334079 | Cyclopropanecarboxylic acid {3-[2-(4-phenyl-butyl)-benzooxazol-7-yl]-propyl}-amide
Type:
Small organic molecule
Emp. Form.:
C24H28N2O2
Mol. Mass.:
376.4913
SMILES:
O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1
Structure:
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