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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50150431
Substrate
n/a
Meas. Tech.
ChEMBL_302554 (CHEMBL839517)
Ki
0.2±n/a nM
Citation
 Denhart, DJ; Purandare, AV; Catt, JD; King, HD; Gao, A; Deskus, JA; Poss, MA; Stark, AD; Torrente, JR; Johnson, G; Mattson, RJ Diaminopyrimidine and diaminopyridine 5-HT7 ligands. Bioorg Med Chem Lett 14:4249-52 (2004) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50150431
Synonyms:
(S)-N2-(2-(4-fluorophenoxy)ethyl)-N4-(1-phenylethyl)pyridine-2,4-diamine | CHEMBL363452 | N*2*-[2-(4-Fluoro-phenoxy)-ethyl]-N*4*-((S)-1-phenyl-ethyl)-pyridine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C21H22FN3O
Mol. Mass.:
351.4173
SMILES:
C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1
Structure:
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