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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50151008
Substrate
n/a
Meas. Tech.
ChEMBL_302800 (CHEMBL838509)
pH
5.5±n/a
Ki
18±n/a nM
Comments
extracted
Citation
 Hooft van Huijsduijnen, R; Sauer, WH; Bombrun, A; Swinnen, D Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs. J Med Chem 47:4142-6 (2004) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50151008
Synonyms:
(7S)-2-[(carboxycarbonyl)amino]-7-({[(5-fluoro-1H-indol-2-yl)carbonyl]amino}methyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid | CHEMBL185891
Type:
Small organic molecule
Emp. Form.:
C20H17FN4O6S
Mol. Mass.:
460.436
SMILES:
OC(=O)C(=O)Nc1sc2C(CNC(=O)c3cc4cc(F)ccc4[nH]3)NCCc2c1C(O)=O
Structure:
Search PDB for entries with ligand similarity: