Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50151408
Substrate
n/a
Meas. Tech.
ChEMBL_306565 (CHEMBL829140)
IC50
40000±n/a nM
Citation
 El-Kabbani, ODarmanin, COka, MSchulze-Briese, CTomizaki, THazemann, IMitschler, APodjarny, A High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor. J Med Chem 47:4530-7 (2004) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50151408
Synonyms:
6-fluoro-2'',5''-dioxo-(2RS,4''R)-spiro[3,4-dihydro-2H-chromene-4,4''-(1''H,2''H-imidazole)]-2-carboxamide | CHEMBL363040
Type:
Small organic molecule
Emp. Form.:
C12H10FN3O4
Mol. Mass.:
279.2239
SMILES:
NC(=O)[C@H]1C[C@@]2(NC(=O)NC2=O)c2cc(F)ccc2O1
Structure:
Search PDB for entries with ligand similarity: