Target
Glutathione reductase, mitochondrial
Ligand
BDBM50096018
Substrate
n/a
Meas. Tech.
ChEMBL_306528 (CHEMBL827279)
IC50
2700±n/a nM
Citation
 Biot, CBauer, HSchirmer, RHDavioud-Charvet, E 5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials. J Med Chem 47:5972-83 (2004) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50096018
Synonyms:
6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID | 6-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-hexanoic acid | CHEMBL135287
Type:
Small organic molecule
Emp. Form.:
C17H18O4
Mol. Mass.:
286.3224
SMILES:
Cc1c(O)c2ccccc2c(O)c1C=CCCCC(O)=O |w:14.16|
Structure:
Search PDB for entries with ligand similarity: