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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50150686
Substrate
n/a
Meas. Tech.
ChEMBL_303384 (CHEMBL839701)
Ki
6.44±n/a nM
Citation
 Holmberg, P; Tedenborg, L; Rosqvist, S; Johansson, AM Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT(7) receptor. Bioorg Med Chem Lett 15:747-50 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50150686
Synonyms:
CHEMBL182792 | [(R)-8-(2,6-Dimethoxy-phenyl)-chroman-3-yl]-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C23H31NO3
Mol. Mass.:
369.4971
SMILES:
CCCN(CCC)[C@H]1COc2c(C1)cccc2-c1c(OC)cccc1OC |wD:7.6,(1.92,-6.31,;1.94,-4.77,;3.27,-4,;3.27,-2.46,;4.6,-1.69,;5.93,-2.46,;7.28,-1.69,;1.94,-1.68,;1.94,-.12,;.58,.65,;-.75,-.12,;-.75,-1.68,;.58,-2.46,;-2.08,-2.43,;-3.41,-1.66,;-3.41,-.12,;-2.08,.65,;-2.09,2.19,;-.76,2.96,;.58,2.19,;1.91,2.96,;-.76,4.5,;-2.1,5.27,;-3.45,4.47,;-3.42,2.94,;-4.75,2.16,;-6.09,2.92,)|
Structure:
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