Reaction Details Report a problem with these data
Target
Estrogen receptor
Ligand
BDBM50162799
Substrate
n/a
Meas. Tech.
ChEMBL_305467 (CHEMBL831077)
IC50
0.3±n/a nM
Citation
Tan, Q; Blizzard, TA; Morgan, JD; Birzin, ET; Chan, W; Yang, YT; Pai, LY; Hayes, EC; DaSilva, CA; Warrier, S; Yudkovitz, J; Wilkinson, HA; Sharma, N; Fitzgerald, PM; Li, S; Colwell, L; Fisher, JE; Adamski, S; Reszka, AA; Kimmel, D; DiNinno, F; Rohrer, SP; Freedman, LP; Schaeffer, JM; Hammond, ML Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs. Bioorg Med Chem Lett 15:1675-81 (2005) [PubMed] Article
More Info.:
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Inhibitor
Name:
BDBM50162799
Synonyms:
(2R,3R,4S)-2-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-5-fluoro-3-(4-hydroxy-phenyl)-4-methyl-chroman-6-ol | CHEMBL181368
Type:
Small organic molecule
Emp. Form.:
C30H34FNO4
Mol. Mass.:
491.5937
SMILES:
C[C@H]1[C@@H]([C@@H](Oc2ccc(O)c(F)c12)c1ccc(OCCN2CCCCCC2)cc1)c1ccc(O)cc1