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Target
Pro-cathepsin H
Ligand
BDBM50163831
Substrate
n/a
Meas. Tech.
ChEMBL_306251 (CHEMBL828384)
IC50
40±n/a nM
Citation
 Deaton, DN; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Shewchuk, LM; Tavares, FX; Willard, DH; Wright, LL Novel and potent cyclic cyanamide-based cathepsin K inhibitors. Bioorg Med Chem Lett 15:1815-9 (2005) [PubMed]  Article 
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain
Type:
PROTEIN
Mol. Mass.:
37402.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459870
Residue:
335
Sequence:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
  
Inhibitor
Name:
BDBM50163831
Synonyms:
(2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-carboxylate | CHEMBL183812
Type:
Small organic molecule
Emp. Form.:
C14H22N2O2
Mol. Mass.:
250.3367
SMILES:
C[C@@H](CC1CCCCC1)OC(=O)C1CCN1C#N
Structure:
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