Reaction Details Report a problem with these data
Target
Melanocortin receptor 3
Ligand
BDBM50165929
Substrate
n/a
Meas. Tech.
ChEMBL_303606 (CHEMBL829695)
Ki
3.1±n/a nM
Citation
 Mayer, JP; Hsiung, HM; Flora, DB; Edwards, P; Smith, DP; Zhang, XY; Gadski, RA; Heiman, ML; Hertel, JL; Emmerson, PJ; Husain, S; O'brien, TP; Kahl, SD; Smiley, DL; Zhang, L; Dimarchi, RD; Yan, LZ Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem 48:3095-8 (2005) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50165929
Synonyms:
Ac-YR[CEH(pCl-dF)RWC]-NH2 | CHEMBL415661
Type:
Small organic molecule
Emp. Form.:
C60H78ClN19O13S2
Mol. Mass.:
1372.964
SMILES:
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]1CSSC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(N)=O
Structure:
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