Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 4
Ligand
BDBM50166318
Substrate
n/a
Meas. Tech.
ChEMBL_305067 (CHEMBL832699)
IC50
0.15±n/a nM
Citation
 Sakashita, H; Kitajima, H; Nakamura, M; Akahoshi, F; Hayashi, Y 1-((S)-gamma-substituted prolyl)-(S)-2-cyanopyrrolidine as a novel series of highly potent DPP-IV inhibitors. Bioorg Med Chem Lett 15:2441-5 (2005) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 4
Synonyms:
Bile canaliculus domain-specific membrane glycoprotein | CD_antigen=CD26 | Cd26 | DPP IV | DPP4_RAT | Dipeptidyl Peptidase IV (DPP-IV) | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 (DDPIV) | Dipeptidyl peptidase 4 60 kDa soluble form | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV 60 kDa soluble form | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dpp4 | GP110 glycoprotein | T-cell activation antigen CD26
Type:
Enzyme
Mol. Mass.:
88084.94
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
767
Sequence:
MKTPWKVLLGLLGVAALVTIITVPVVLLNKDEAAADSRRTYTLADYLKNTFRVKSYSLRWVSDSEYLYKQENNILLFNAEHGNSSIFLENSTFEIFGDSISDYSVSPDRLFVLLEYNYVKQWRHSYTASYSIYDLNKRQLITEEKIPNNTQWITWSQEGHKLAYVWKNDIYVKIEPHLPSHRITSTGKENVIFNGINDWVYEEEIFGAYSALWWSPNGTFLAYAQFNDTGVPLIEYSFYSDESLQYPKTVWIPYPKAGAVNPTVKFFIVNTDSLSSTTTTIPMQITAPASVTTGDHYLCDVAWVSEDRISLQWLRRIQNYSVMAICDYDKTTLVWNCPTTQEHIETSATGWCGRFRPAEPHFTSDGSSFYKIVSDKDGYKHICQFQKDRKPEQVCTFITKGAWEVISIEALTSDYLYYISNEYKEMPGGRNLYKIQLTDHTNKKCLSCDLNPERCQYYSVSLSKEAKYYQLGCRGPGLPLYTLHRSTDQKELRVLEDNSALDKMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKKYPLLIDVYAGPCSQKADAAFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINKRLGTLEVEDQIEAARQFLKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLR
  
Inhibitor
Name:
BDBM50166318
Synonyms:
(S)-1-[(2S,4S)-4-(3-Chloro-4-cyano-phenylamino)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile | CHEMBL194717
Type:
Small organic molecule
Emp. Form.:
C17H18ClN5O
Mol. Mass.:
343.811
SMILES:
Clc1cc(N[C@@H]2CN[C@@H](C2)C(=O)N2CCC[C@H]2C#N)ccc1C#N
Structure:
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