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Target
Cannabinoid receptor 1
Ligand
BDBM50176401
Substrate
n/a
Meas. Tech.
ChEMBL_333260 (CHEMBL859079)
Ki
28±n/a nM
Citation
 Carpino, PA; Griffith, DA; Sakya, S; Dow, RL; Black, SC; Hadcock, JR; Iredale, PA; Scott, DO; Fichtner, MW; Rose, CR; Day, R; Dibrino, J; Butler, M; Debartolo, DB; Dutcher, D; Gautreau, D; Lizano, JS; O'connor, RE; Sands, MA; Kelly-Sullivan, D; Ward, KM New bicyclic cannabinoid receptor-1 (CB1-R) antagonists. Bioorg Med Chem Lett 16:731-6 (2005) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50176401
Synonyms:
3-(2-chlorophenyl)-2-(4-chlorophenyl)-6-(2,2,2-trifluoroethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | CHEMBL380937
Type:
Small organic molecule
Emp. Form.:
C19H11Cl2F3N4O
Mol. Mass.:
439.218
SMILES:
FC(F)(F)Cn1cnc2c(-c3ccccc3Cl)n(nc2c1=O)-c1ccc(Cl)cc1 |(32.92,3.31,;31.59,4.08,;32.37,5.41,;30.82,2.74,;30.26,4.85,;28.92,4.08,;27.59,4.86,;26.27,4.08,;26.26,2.55,;25.12,1.51,;23.61,1.82,;22.59,.68,;21.09,.99,;20.61,2.46,;21.63,3.61,;23.13,3.29,;24.16,4.43,;25.75,.11,;27.28,.27,;27.59,1.78,;28.92,2.54,;30.26,1.77,;24.99,-1.23,;23.45,-1.24,;22.68,-2.57,;23.45,-3.9,;22.69,-5.24,;25,-3.89,;25.76,-2.56,)|
Structure:
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