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Target
Cannabinoid receptor 1
Ligand
BDBM50176410
Substrate
n/a
Meas. Tech.
ChEMBL_333262 (CHEMBL859083)
Ki
5±n/a nM
Citation
 Carpino, PA; Griffith, DA; Sakya, S; Dow, RL; Black, SC; Hadcock, JR; Iredale, PA; Scott, DO; Fichtner, MW; Rose, CR; Day, R; Dibrino, J; Butler, M; Debartolo, DB; Dutcher, D; Gautreau, D; Lizano, JS; O'connor, RE; Sands, MA; Kelly-Sullivan, D; Ward, KM New bicyclic cannabinoid receptor-1 (CB1-R) antagonists. Bioorg Med Chem Lett 16:731-6 (2005) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50176410
Synonyms:
2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2-fluoroethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | CHEMBL202583
Type:
Small organic molecule
Emp. Form.:
C19H13Cl2FN4O
Mol. Mass.:
403.237
SMILES:
FCCn1cnc2c(-c3ccc(Cl)cc3)n(nc2c1=O)-c1ccccc1Cl
Structure:
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