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Target
Alpha-1D adrenergic receptor
Ligand
BDBM50176524
Substrate
n/a
Meas. Tech.
ChEMBL_329195 (CHEMBL863435)
IC50
>100000±n/a nM
Citation
 Vilar, S; Quezada, E; Santana, L; Uriarte, E; Yánez, M; Fraiz, N; Alcaide, C; Cano, E; Orallo, F Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids. Bioorg Med Chem Lett 16:257-61 (2005) [PubMed]  Article 
Target
Name:
Alpha-1D adrenergic receptor
Synonyms:
ADA1D_RAT | Adra1a | Adra1d | Alpha adrenergic receptor 1A and 1D | Alpha-1D adrenergic receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1
Type:
Protein
Mol. Mass.:
59375.97
Organism:
Rattus norvegicus (Rat)
Description:
P23944
Residue:
561
Sequence:
MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
  
Inhibitor
Name:
BDBM50176524
Synonyms:
6,8-dimethoxy-3-(3',5'-dimethoxyphenyl)coumarin | CHEMBL378382
Type:
Small organic molecule
Emp. Form.:
C19H18O6
Mol. Mass.:
342.3426
SMILES:
COc1cc(OC)cc(c1)-c1cc2cc(OC)cc(OC)c2oc1=O
Structure:
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