Reaction Details Report a problem with these data
Target
Pro-cathepsin H
Ligand
BDBM50148296
Substrate
n/a
Meas. Tech.
ChEMBL_334150 (CHEMBL868301)
IC50
40±n/a nM
Citation
Adkison, KK; Barrett, DG; Deaton, DN; Gampe, RT; Hassell, AM; Long, ST; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg Med Chem Lett 16:978-83 (2006) [PubMed] Article
More Info.:
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain
Type:
PROTEIN
Mol. Mass.:
37402.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459870
Residue:
335
Sequence:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
Inhibitor
Name:
BDBM50148296
Synonyms:
((S)-1-Formyl-pentyl)-carbamic acid (S)-1-methyl-2-phenyl-ethyl ester | (S)-1-phenylpropan-2-yl (S)-1-oxohexan-2-ylcarbamate | CHEMBL114161
Type:
Small organic molecule
Emp. Form.:
C16H23NO3
Mol. Mass.:
277.3587
SMILES:
CCCC[C@H](NC(=O)O[C@@H](C)Cc1ccccc1)C=O