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Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM50179936
Substrate
n/a
Meas. Tech.
ChEMBL_340361 (CHEMBL864402)
IC50
2±n/a nM
Citation
 Fink, BE; Gavai, AV; Tokarski, JS; Goyal, B; Misra, R; Xiao, HY; Kimball, SD; Han, WC; Norris, D; Spires, TE; You, D; Gottardis, MM; Lorenzi, MV; Vite, GD Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3. Bioorg Med Chem Lett 16:1532-6 (2006) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
17-beta-hydroxysteroid dehydrogenase type 3 | DHB3_HUMAN | EDH17B3 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | SDR12C2
Type:
Enzyme
Mol. Mass.:
34525.39
Organism:
Homo sapiens (Human)
Description:
P37058
Residue:
310
Sequence:
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYVAYLKLNTKVR
  
Inhibitor
Name:
BDBM50179936
Synonyms:
CHEMBL382563 | N-[2-(5-acetyl-2-chloro-5,6,11,12-tetrahydro-dibenzo[b,f]azocin-8-yl)-phenyl]-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C24H23ClN2O3S
Mol. Mass.:
454.969
SMILES:
CC(=O)N1Cc2cc(ccc2CCc2cc(Cl)ccc12)-c1ccccc1NS(C)(=O)=O
Structure:
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