Reaction Details Report a problem with these data
Target
Methionine aminopeptidase
Ligand
BDBM50180753
Substrate
n/a
Meas. Tech.
ChEMBL_329657 (CHEMBL865844)
IC50
>10000±n/a nM
Citation
 Schiffmann, R; Neugebauer, A; Klein, CD Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions. J Med Chem 49:511-22 (2006) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM50180753
Synonyms:
(5-benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester | CHEMBL685 | MBDZ | MEBENDAZOLE | Vermox | methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate
Type:
Small organic molecule
Emp. Form.:
C16H13N3O3
Mol. Mass.:
295.2927
SMILES:
COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1ccccc1
Structure:
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