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Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Ligand
BDBM50181148
Substrate
n/a
Meas. Tech.
ChEMBL_345851 (CHEMBL860877)
IC50
119±n/a nM
Citation
 Haemers, T; Wiesner, J; Van Poecke, S; Goeman, J; Henschker, D; Beck, E; Jomaa, H; Van Calenbergh, S Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors. Bioorg Med Chem Lett 16:1888-91 (2006) [PubMed]  Article 
Target
Name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms:
1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXP) | 1-Deoxyxylulose 5-phosphate reductoisomerase (DXR) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) | 2-C-methyl-D-erythritol 4-phosphate synthase | DXP reductoisomerase | DXR_ECOLI | dxr | ispC | yaeM
Type:
Protein
Mol. Mass.:
43384.52
Organism:
Escherichia coli
Description:
P45568
Residue:
398
Sequence:
MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS
  
Inhibitor
Name:
BDBM50181148
Synonyms:
1-(3,4-dichlorophenyl)-3-(N-hydroxyacetamido)propylphosphonic acid | CHEMBL204107
Type:
Small organic molecule
Emp. Form.:
C11H14Cl2NO5P
Mol. Mass.:
342.112
SMILES:
CC(=O)N(O)CCC(c1ccc(Cl)c(Cl)c1)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: