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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50183665
Substrate
n/a
Meas. Tech.
ChEMBL_350835 (CHEMBL869689)
EC50
4400±n/a nM
Citation
 del Olmo, E; Barboza, B; Ybarra, MI; López-Pérez, JL; Carrón, R; Sevilla, MA; Boselli, C; San Feliciano, A Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett 16:2786-90 (2006) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_RAT | Adra1a | Adra1c | Alpha-1 adrenoreceptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | adrenergic Alpha1A
Type:
Protein
Mol. Mass.:
51620.15
Organism:
Rattus norvegicus (Rat)
Description:
P43140
Residue:
466
Sequence:
MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
  
Inhibitor
Name:
BDBM50183665
Synonyms:
4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one | CHEMBL207277
Type:
Small organic molecule
Emp. Form.:
C18H15ClN2O
Mol. Mass.:
310.778
SMILES:
Clc1ccc(Cc2nn(CC=C)c(=O)c3ccccc23)cc1
Structure:
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