Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50186440
Substrate
n/a
Meas. Tech.
ChEMBL_369836 (CHEMBL865957)
IC50
550±n/a nM
Citation
 Cheng, KF; Al-Abed, Y Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem Lett 16:3376-9 (2006) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50186440
Synonyms:
(R)-1-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)-4,4-dimethylpentan-2-one | CHEMBL209588
Type:
Small organic molecule
Emp. Form.:
C16H20FNO3
Mol. Mass.:
293.3333
SMILES:
CC(C)(C)CC(=O)C[C@H]1CC(=NO1)c1ccc(O)c(F)c1 |c:10|
Structure:
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