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Target
RNA-directed RNA polymerase
Ligand
BDBM50187230
Substrate
n/a
Meas. Tech.
ChEMBL_356302 (CHEMBL869357)
IC50
2000±n/a nM
Citation
 Gopalsamy, A; Chopra, R; Lim, K; Ciszewski, G; Shi, M; Curran, KJ; Sukits, SF; Svenson, K; Bard, J; Ellingboe, JW; Agarwal, A; Krishnamurthy, G; Howe, AY; Orlowski, M; Feld, B; O'Connell, J; Mansour, TS Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site. J Med Chem 49:3052-5 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50187230
Synonyms:
(2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]piperidine-2-carboxylic acid | CHEMBL208803
Type:
Small organic molecule
Emp. Form.:
C12H13Cl2NO5S
Mol. Mass.:
354.206
SMILES:
OC(=O)[C@@H]1CCCCN1S(=O)(=O)c1cc(Cl)cc(Cl)c1O
Structure:
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