Target
Estrogen receptor beta
Ligand
BDBM50187966
Substrate
n/a
Meas. Tech.
ChEMBL_383639 (CHEMBL868002)
IC50
1.6±n/a nM
Citation
 Wilkening, RRRatcliffe, RWFried, AKMeng, DSun, WColwell, LLambert, SGreenlee, MNilsson, SThorsell, AMojena, MTudela, CFrisch, KChan, WBirzin, ETRohrer, SPHammond, ML Estrogen receptor beta-subtype selective tetrahydrofluorenones: use of a fused pyrazole as a phenol bioisostere. Bioorg Med Chem Lett 16:3896-901 (2006) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50187966
Synonyms:
(S)-6-bromo-9a-(2-cyclopropyl-ethyl)-8,9,9a,10-tetrahydro-3H-2,3-diaza-cyclopenta[a]fluoren-7-one | CHEMBL211800
Type:
Small organic molecule
Emp. Form.:
C19H19BrN2O
Mol. Mass.:
371.271
SMILES:
BrC1=C2c3ccc4[nH]ncc4c3C[C@]2(CCC2CC2)CCC1=O |c:1|
Structure:
Search PDB for entries with ligand similarity: