Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50191523
Substrate
n/a
Meas. Tech.
ChEMBL_376990 (CHEMBL866684)
IC50
170±n/a nM
Citation
 Hirashima, S; Suzuki, T; Ishida, T; Noji, S; Yata, S; Ando, I; Komatsu, M; Ikeda, S; Hashimoto, H Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem 49:4721-36 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50191523
Synonyms:
2-{4-[5-(4-chlorophenyl)-2-methylthiazol-4-ylmethoxy]phenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | CHEMBL212583
Type:
Small organic molecule
Emp. Form.:
C31H28ClN3O3S
Mol. Mass.:
558.09
SMILES:
Cc1nc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(s1)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: