Target
RNA-directed RNA polymerase
Ligand
BDBM50191547
Substrate
n/a
Meas. Tech.
ChEMBL_376990 (CHEMBL866684)
IC50
55±n/a nM
Citation
 Hirashima, SSuzuki, TIshida, TNoji, SYata, SAndo, IKomatsu, MIkeda, SHashimoto, H Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem 49:4721-36 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50191547
Synonyms:
2-[4-(4-chloro-4'-cyanobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | CHEMBL209681
Type:
Small organic molecule
Emp. Form.:
C34H28ClN3O3
Mol. Mass.:
562.057
SMILES:
OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2ccc(cc2)C#N)cc1
Structure:
Search PDB for entries with ligand similarity: