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Target
Beta-3 adrenergic receptor
Ligand
BDBM50193803
Substrate
n/a
Meas. Tech.
ChEMBL_424173 (CHEMBL906194)
EC50
25±n/a nM
Citation
 Finley, DR; Bell, MG; Borel, AG; Bloomquist, WE; Cohen, ML; Heiman, ML; Kriauciunas, A; Matthews, DP; Miles, T; Neel, DA; Rito, CJ; Sall, DJ; Shuker, AJ; Stephens, TW; Tinsley, FC; Winter, MA; Jesudason, CD Potent benzimidazolone based human beta(3)-adrenergic receptor agonists. Bioorg Med Chem Lett 16:5691-4 (2006) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3_RAT | Adrb3 | Adrb3r | Adrenergic receptor beta | Beta-3 adrenergic receptor
Type:
PROTEIN
Mol. Mass.:
43161.83
Organism:
Rattus norvegicus
Description:
ChEMBL_1509452
Residue:
400
Sequence:
MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
  
Inhibitor
Name:
BDBM50193803
Synonyms:
(S)-6-(4-(2-(2-hydroxy-3-(3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yloxy)propylamino)-2-methylpropyl)phenoxy)nicotinamide | CHEMBL386016
Type:
Small organic molecule
Emp. Form.:
C27H31N5O5
Mol. Mass.:
505.5655
SMILES:
Cn1c2c(OC[C@@H](O)CNC(C)(C)Cc3ccc(Oc4ccc(cn4)C(N)=O)cc3)cccc2[nH]c1=O
Structure:
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