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Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM50195500
Substrate
n/a
Meas. Tech.
ChEMBL_425008 (CHEMBL911428)
IC50
>10000±n/a nM
Citation
 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorg Med Chem Lett 16:6241-5 (2006) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-beta-hydroxysteroid dehydrogenase 2 | DHI2_RAT | Hsd11b2 | Hsd11k
Type:
PROTEIN
Mol. Mass.:
43740.05
Organism:
Rattus norvegicus
Description:
ChEMBL_735659
Residue:
400
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNGPGALELRARCSPRLKLLQMDLTKPEDISRVLEITKAHTASTGLWGLVNNAGLNMVVADVELSPVVTFRECMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFSCELLPWGIKVSIIQPGCFKTEAVTNVNLWEKRKQLLLANLPRELLQAYGEDYIEHLHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYTGRGLGLMYFIHHYLPGGLRRRFLQNFFISHLLPRALRPGQPGPVHDTTQDPNPSPTVSAL
  
Inhibitor
Name:
BDBM50195500
Synonyms:
(4-amino-3,5-dichlorophenyl)(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone | CHEMBL223424
Type:
Small organic molecule
Emp. Form.:
C17H15Cl2F3N4O
Mol. Mass.:
419.228
SMILES:
Nc1c(Cl)cc(cc1Cl)C(=O)N1CCN(CC1)c1ccc(cn1)C(F)(F)F
Structure:
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