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Target
Histone deacetylase 2b
Ligand
BDBM50234055
Substrate
n/a
Meas. Tech.
ChEMBL_416717 (CHEMBL909983)
IC50
8±n/a nM
Citation
 Mai, A; Massa, S; Rotili, D; Simeoni, S; Ragno, R; Botta, G; Nebbioso, A; Miceli, M; Altucci, L; Brosch, G Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J Med Chem 49:6046-56 (2006) [PubMed]  Article 
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Zea mays
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
  
Inhibitor
Name:
BDBM50234055
Synonyms:
CHEMBL217494 | N-hydroxy-5-(3,4-dihydro-4-oxo-6-phenyl-2-pyrimidinylthio)pentanamide | N-hydroxy-5-(6-oxo-4-phenyl-1,6-dihydropyrimidin-2-ylthio)pentanamide
Type:
Small organic molecule
Emp. Form.:
C15H17N3O3S
Mol. Mass.:
319.379
SMILES:
ONC(=O)CCCCSc1nc(cc(=O)[nH]1)-c1ccccc1
Structure:
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