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Target
Cycloartenol-C-24-methyltransferase
Ligand
BDBM50195628
Substrate
n/a
Meas. Tech.
ChEMBL_415082 (CHEMBL912396)
IC50
>100000±n/a nM
Citation
 Gros, L; Lorente, SO; Jimenez, CJ; Yardley, V; Rattray, L; Wharton, H; Little, S; Croft, SL; Ruiz-Perez, LM; Gonzalez-Pacanowska, D; Gilbert, IH Evaluation of azasterols as anti-parasitics. J Med Chem 49:6094-103 (2006) [PubMed]  Article 
Target
Name:
Cycloartenol-C-24-methyltransferase
Synonyms:
24-sterol C-methyltransferase | CPH | SMT1 | SMT1_ARATH
Type:
PROTEIN
Mol. Mass.:
38266.01
Organism:
Arabidopsis thaliana
Description:
ChEMBL_415082
Residue:
336
Sequence:
MDLASNLGGKIDKSDVLTAVEKYEQYHVFHGGNEEERKANYTDMVNKYYDLATSFYEYGWGESFHFAQRWKGESLRESIKRHEHFLALQLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFDPDNAEHQKIKGEIEIGDGLPDIRLTTKCLEALKQAGFEVIWEKDLAKDSPVPWYLPLDKNHFSLSSFRLTAVGRFITKNMVKILEYIRLAPQGSQRVSNFLEQAAEGLVDGGRREIFTPMYFFLARKPE
  
Inhibitor
Name:
BDBM50195628
Synonyms:
3beta-ol-23,24-bisnor-5-en-22-(heptanoic acid) amide | CHEMBL217513
Type:
Small organic molecule
Emp. Form.:
C29H47NO4
Mol. Mass.:
473.6878
SMILES:
C[C@@H]([C@H]1CC[C@H]2C3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(=O)NCCCCCCC(O)=O |t:8|
Structure:
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