Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50197401
Substrate
n/a
Meas. Tech.
ChEMBL_453207 (CHEMBL902361)
Ki
13±n/a nM
Citation
 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors. Bioorg Med Chem Lett 17:527-32 (2007) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50197401
Synonyms:
2-methyl-2-phenoxy-N-(5-sulfamoyl-adamantan-2-yl)-propionamide | CHEMBL241719
Type:
Small organic molecule
Emp. Form.:
C20H28N2O4S
Mol. Mass.:
392.512
SMILES:
CC(C)(Oc1ccccc1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O |w:16.23,14.25,18.18,wU:13.13,wD:20.26,TLB:13:14:21:17.18.19,12:13:21.16.17:19,THB:15:16:19:22.14.13,15:14:21.16.17:19,13:18:21:22.15.14,TEB:17:18:22:21.16.15,(1.42,4.21,;2.23,2.91,;3.05,1.6,;3.56,3.69,;4.9,2.93,;4.91,1.39,;6.24,.63,;7.57,1.41,;7.56,2.96,;6.22,3.71,;.95,2.06,;1.04,.52,;-.43,2.74,;-1.71,1.89,;-1.72,.36,;-2.74,-.92,;-4.14,-.35,;-4.15,1.24,;-3.11,2.47,;-4.46,1.99,;-4.45,.51,;-5.64,-.77,;-3.12,.02,;-5.94,.92,;-7.44,1.32,;-5.54,2.4,;-6.35,-.57,)|
Structure:
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