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Target
Glucagon receptor
Ligand
BDBM50202051
Substrate
n/a
Meas. Tech.
ChEMBL_423446 (CHEMBL911099)
IC50
56±n/a nM
Citation
 Lau, J; Behrens, C; Sidelmann, UG; Knudsen, LB; Lundt, B; Sams, C; Ynddal, L; Brand, CL; Pridal, L; Ling, A; Kiel, D; Plewe, M; Shi, S; Madsen, P New beta-alanine derivatives are orally available glucagon receptor antagonists. J Med Chem 50:113-28 (2007) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50202051
Synonyms:
CHEMBL373824 | trans-3-(4-((1-(4-tert-butylcyclohexyl)-3-(2-cyano-4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid
Type:
Small organic molecule
Emp. Form.:
C30H35F3N4O5
Mol. Mass.:
588.6179
SMILES:
CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1C#N |r,wU:7.10,wD:4.3,(7.81,-36.16,;6.27,-36.14,;4.73,-36.12,;6.32,-34.6,;6.22,-37.68,;4.86,-38.41,;4.81,-39.95,;6.11,-40.75,;7.48,-40.02,;7.52,-38.49,;6.07,-42.29,;4.72,-43.02,;3.4,-42.22,;2.04,-42.95,;.73,-42.14,;.78,-40.59,;2.15,-39.88,;3.46,-40.68,;-.53,-39.78,;-.48,-38.24,;-1.88,-40.51,;-3.19,-39.7,;-4.55,-40.43,;-5.86,-39.62,;-5.81,-38.09,;-7.21,-40.36,;7.38,-43.1,;8.74,-42.37,;7.34,-44.64,;5.98,-45.37,;4.68,-44.56,;3.32,-45.29,;3.28,-46.83,;1.92,-47.56,;1.88,-49.1,;1.87,-50.64,;.34,-49.07,;3.42,-49.13,;4.6,-47.64,;5.95,-46.9,;7.26,-47.7,;8.57,-48.5,)|
Structure:
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