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Target
Glucagon receptor
Ligand
BDBM50144009
Substrate
n/a
Meas. Tech.
ChEMBL_423457 (CHEMBL909993)
IC50
56±n/a nM
Citation
 Lau, J; Behrens, C; Sidelmann, UG; Knudsen, LB; Lundt, B; Sams, C; Ynddal, L; Brand, CL; Pridal, L; Ling, A; Kiel, D; Plewe, M; Shi, S; Madsen, P New beta-alanine derivatives are orally available glucagon receptor antagonists. J Med Chem 50:113-28 (2007) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GL-R | GLR_RAT | Gcgr
Type:
PROTEIN
Mol. Mass.:
55053.40
Organism:
Rattus norvegicus
Description:
ChEMBL_1450588
Residue:
485
Sequence:
MLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
  
Inhibitor
Name:
BDBM50144009
Synonyms:
3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluoromethoxy-phenyl)-ureidomethyl]-benzoylamino}-propionic acid | CHEMBL62444 | trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid
Type:
Small organic molecule
Emp. Form.:
C29H36F3N3O5
Mol. Mass.:
563.6084
SMILES:
CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |wU:4.3,wD:7.10,(10.18,2.9,;9.39,1.56,;8.05,2.34,;8.62,.21,;10.74,.78,;12.08,1.53,;13.41,.77,;13.41,-.77,;12.07,-1.54,;10.74,-.77,;14.74,-1.54,;14.74,-3.07,;13.39,-3.86,;12.07,-3.1,;10.74,-3.86,;10.74,-5.4,;12.07,-6.17,;13.41,-5.4,;9.41,-6.19,;9.43,-7.72,;8.06,-5.42,;6.74,-6.2,;5.4,-5.44,;4.07,-6.23,;2.73,-5.47,;4.07,-7.77,;16.06,-.77,;16.06,.77,;17.39,-1.54,;18.71,-.77,;20.04,-1.53,;21.38,-.77,;21.36,.78,;22.71,1.56,;22.7,3.09,;21.17,3.11,;24.23,3.11,;22.71,4.62,;20.04,1.55,;18.71,.77,)|
Structure:
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