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Target
Neutrophil collagenase
Ligand
BDBM50204004
Substrate
n/a
Meas. Tech.
ChEMBL_441980 (CHEMBL891124)
IC50
11000±n/a nM
Citation
 Vidal, A; Sabatini, M; Rolland-Valognes, G; Renard, P; Madelmont, JC; Mounetou, E Synthesis and in vitro evaluation of targeted tetracycline derivatives: effects on inhibition of matrix metalloproteinases. Bioorg Med Chem 15:2368-74 (2007) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50204004
Synonyms:
1,4,4a,5,5a,6,11,12a-octahydro-2-aminocarbo-nyl-3,5,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-naphthacen-4-trimethylammonium iodide | CHEMBL242074
Type:
Small organic molecule
Emp. Form.:
C23H27N2O8
Mol. Mass.:
459.4685
SMILES:
C[C@@H]1C2[C@@H](O)C3[C@@H](C(=O)C(C(N)=O)C(=O)[C@@]3(O)C(=O)C2C(=O)c2c(O)cccc12)[N+](C)(C)C
Structure:
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