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Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50204396
Substrate
n/a
Meas. Tech.
ChEMBL_447058 (CHEMBL897359)
IC50
<1±n/a nM
Citation
 Chen, XT; Ghavimi, B; Corbett, RL; Xue, CB; Liu, RQ; Covington, MB; Qian, M; Vaddi, KG; Christ, DD; Hartman, KD; Ribadeneira, MD; Trzaskos, JM; Newton, RC; Decicco, CP; Duan, JJ A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors. Bioorg Med Chem Lett 17:1865-70 (2007) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Sus scrofa (pig)
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
  
Inhibitor
Name:
BDBM50204396
Synonyms:
(3S,4S)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methyl)benzamido)pyrrolidine-3-carboxamide | CHEMBL391873
Type:
Small organic molecule
Emp. Form.:
C23H24N4O3
Mol. Mass.:
404.4617
SMILES:
Cc1cc(Cc2ccc(cc2)C(=O)N[C@@H]2CNC[C@@H]2C(=O)NO)c2ccccc2n1
Structure:
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