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Target
Protein tyrosine phosphatase receptor type C-associated protein
Ligand
BDBM50212333
Substrate
n/a
Meas. Tech.
ChEMBL_436619 (CHEMBL904929)
IC50
1200±n/a nM
Citation
 Dawson, MI; Xia, Z; Liu, G; Ye, M; Fontana, JA; Farhana, L; Patel, BB; Arumugarajah, S; Bhuiyan, M; Zhang, XK; Han, YH; Stallcup, WB; Fukushi, J; Mustelin, T; Tautz, L; Su, Y; Harris, DL; Waleh, N; Hobbs, PD; Jong, L; Chao, WR; Schiff, LJ; Sani, BP An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity. J Med Chem 50:2622-39 (2007) [PubMed]  Article 
Target
Name:
Protein tyrosine phosphatase receptor type C-associated protein
Synonyms:
CD45-AP | CD45-associated protein | LPAP | Lymphocyte phosphatase-associated phosphoprotein | PTCA_HUMAN | PTPRC-associated protein | PTPRCAP
Type:
PROTEIN
Mol. Mass.:
21182.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210870
Residue:
206
Sequence:
MALPCTLGLGMLLALPGALGSGGSAEDSVGSSSVTVVLLLLLLLLLATGLALAWRRLSRDSGGYYHPARLGAALWGRTRRLLWASPPGRWLQARAELGSTDNDLERQEDEQDTDYDHVADGGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLVLGSPGPASAGGSAEALLSDLHAFAGSAAWDDSARAAGGQGLHVTAL
  
Inhibitor
Name:
BDBM50212333
Synonyms:
5-[3'-(1-adamantyl)-2-chloro-4'-hydroxy-4-biphenyl]-1H-tetrazole | CHEMBL227622
Type:
Small organic molecule
Emp. Form.:
C23H23ClN4O
Mol. Mass.:
406.908
SMILES:
Oc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc(cc1Cl)-c1nnn[nH]1 |TLB:6:7:10:14.13.12,THB:8:9:12:16.7.15,8:7:10.9.14:12,15:7:10:14.13.12,15:13:10:16.8.7|
Structure:
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