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TargetProtein tyrosine phosphatase receptor type C-associated protein
LigandBDBM50212331
Substrate/Competitorn/a
Meas. Tech.ChEMBL_436619
IC50 2300±n/a nM
Citation Dawson, MIXia, ZLiu, GYe, MFontana, JAFarhana, LPatel, BBArumugarajah, SBhuiyan, MZhang, XKHan, YHStallcup, WBFukushi, JMustelin, TTautz, LSu, YHarris, DLWaleh, NHobbs, PDJong, LChao, WRSchiff, LJSani, BP An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity. J Med Chem50:2622-39 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein tyrosine phosphatase receptor type C-associated protein
Name:Protein tyrosine phosphatase receptor type C-associated protein
Synonyms:CD45-AP | CD45-associated protein | Lymphocyte phosphatase-associated phosphoprotein | PTPRC-associated protein
Type:PROTEIN
Mol. Mass.:21182.08
Organism:Homo sapiens (Human)
Description:ChEMBL_210870
Residue:206
Sequence:
MALPCTLGLGMLLALPGALGSGGSAEDSVGSSSVTVVLLLLLLLLLATGLALAWRRLSRD
SGGYYHPARLGAALWGRTRRLLWASPPGRWLQARAELGSTDNDLERQEDEQDTDYDHVAD
GGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLVLGSPGPASAGGSAEALLSDL
HAFAGSAAWDDSARAAGGQGLHVTAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50212331
NameBDBM50212331
Synonyms:5-[1-(3'-adamantan-1-yl-2-chloro-4'-hydroxy-biphenyl-4-yl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione | CHEMBL376571
TypeSmall organic molecule
Emp. Form.C26H24ClNO3S
Mol. Mass.465.992
SMILESOC1=NC(=O)C(S1)=Cc1ccc(c(Cl)c1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2 |w:7.8,t:1,TLB:20:22:25:29.28.27,THB:23:24:27:31.22.30,23:22:25.24.29:27,30:22:25:29.28.27,30:28:25:31.23.22|
Structure
n/a