Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM50214231
Substrate
n/a
Meas. Tech.
ChEMBL_456298 (CHEMBL888309)
Ki
38±n/a nM
Citation
Washburn, WN; Harper, TW; Wu, G; Godfrey, JD; McCann, P; Girotra, R; Shao, C; Zhang, H; Gavai, A; Mikkilineni, A; Dejneka, T; Ahmed, S; Caringal, Y; Hangeland, J; Zhang, M; Cheng, PT; Russell, AD; Skwish, S; Slusarchyk, DA; Allen, GT; Frohlich, BH; Abboa-Offei, BE; Cap, M; Waldron, TL; George, RJ; Tesfamariam, B; Dickinson, KE; Seymour, AA; Sher, PM Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations. Bioorg Med Chem Lett 17:4290-6 (2007) [PubMed] Article
More Info.:
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Inhibitor
Name:
BDBM50214231
Synonyms:
CHEMBL249359 | N-(5-((S)-3-((R)-1-(3,4-dichlorophenyl)-2-phenylethylamino)-2-hydroxypropyl)-2-hydroxyphenyl)methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C24H26Cl2N2O4S
Mol. Mass.:
509.445
SMILES:
CS(=O)(=O)Nc1cc(C[C@H](O)CN[C@H](Cc2ccccc2)c2ccc(Cl)c(Cl)c2)ccc1O