Reaction Details Report a problem with these data
Target
Macrophage metalloelastase
Ligand
BDBM50216172
Substrate
n/a
Meas. Tech.
ChEMBL_439905 (CHEMBL890224)
IC50
121000±n/a nM
Citation
 Sasanelli, R; Boccarelli, A; Giordano, D; Laforgia, M; Arnesano, F; Natile, G; Cardellicchio, C; Capozzi, MA; Coluccia, M Platinum complexes can inhibit matrix metalloproteinase activity: platinum-diethyl[(methylsulfinyl)methyl]phosphonate complexes as inhibitors of matrix metalloproteinases 2, 3, 9, and 12. J Med Chem 50:3434-41 (2007) [PubMed]  Article 
Target
Name:
Macrophage metalloelastase
Synonyms:
HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:
Enzyme
Mol. Mass.:
54012.99
Organism:
Homo sapiens (Human)
Description:
P39900
Residue:
470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
  
Inhibitor
Name:
BDBM50216172
Synonyms:
(Dichloro-phosphono-methyl)-phosphonic acid | CHEMBL12318 | bisphosphonate clodronate | clodronic acid
Type:
Small organic molecule
Emp. Form.:
CH4Cl2O6P2
Mol. Mass.:
244.892
SMILES:
OP(O)(=O)C(Cl)(Cl)P(O)(O)=O
Structure:
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