Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50220836
Substrate
n/a
Meas. Tech.
ChEMBL_449367 (CHEMBL899634)
EC50
1514±n/a nM
Citation
 Skinner, PJ; Cherrier, MC; Webb, PJ; Shin, YJ; Gharbaoui, T; Lindstrom, A; Hong, V; Tamura, SY; Dang, HT; Pride, CC; Chen, R; Richman, JG; Connolly, DT; Semple, G Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett 17:5620-3 (2007) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50220836
Synonyms:
5-(4-fluoro-5-methyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL235231
Type:
Small organic molecule
Emp. Form.:
C5H5FN6
Mol. Mass.:
168.1318
SMILES:
Cc1[nH]nc(-c2nnn[nH]2)c1F
Structure:
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