Target
Polyunsaturated fatty acid lipoxygenase ALOX15B
Ligand
BDBM32020
Substrate
n/a
Meas. Tech.
ChEMBL_457827 (CHEMBL924097)
IC50
11000±n/a nM
Citation
 Vasquez-Martinez, YOhri, RVKenyon, VHolman, TRSepúlveda-Boza, S Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. Bioorg Med Chem 15:7408-25 (2007) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15B
Synonyms:
15-LOX-2 | 15-Lipo-oxygenase type 2 (15-LOX-2) | 15-Lipoxygenase-2 (15-LOX-2) | 15-lipoxygenase 2 | ALOX15B | Arachidonate 15-lipoxygenase type II | Arachidonate 15-lipoxygenase, type II | Arachidonate 15-lipoxygenase-2 | Epithelial 15-lipoxygenase-2 | LX15B_HUMAN
Type:
Protein
Mol. Mass.:
75850.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
676
Sequence:
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI
  
Inhibitor
Name:
BDBM32020
Synonyms:
4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyrocatechol | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol | 4-[4-[3,4-bis(oxidanyl)phenyl]-2,3-dimethyl-butyl]benzene-1,2-diol | BDBM166684 | CHEMBL52 | LOX inhibitor, N/A | MLS000069451 | NORDIHYDROGUAIARETIC ACID | Nordihydroguaiaretic acid (NDGA) | SMR000059049 | US10857082, Compound 2.18 | cid_4534
Type:
Small organic molecule
Emp. Form.:
C18H22O4
Mol. Mass.:
302.3649
SMILES:
CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1
Structure:
Search PDB for entries with ligand similarity: