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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50236052
Substrate
n/a
Meas. Tech.
ChEMBL_462928 (CHEMBL929862)
Ki
4.5±n/a nM
Citation
 Lai, G; Merritt, JR; He, Z; Feng, D; Chao, J; Czarniecki, MF; Rokosz, LL; Stauffer, TM; Rindgen, D; Taveras, AG Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists. Bioorg Med Chem Lett 18:1864-8 (2008) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50236052
Synonyms:
(R)-3-(2-(cyclopropyl(3,5-difluorophenyl)methylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide | CHEMBL254776
Type:
Small organic molecule
Emp. Form.:
C23H21F2N3O4
Mol. Mass.:
441.4273
SMILES:
CN(C)C(=O)c1cccc(Nc2c(N[C@H](C3CC3)c3cc(F)cc(F)c3)c(=O)c2=O)c1O
Structure:
Search PDB for entries with ligand similarity: