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Target
DNA polymerase beta
Ligand
BDBM50241924
Substrate
n/a
Meas. Tech.
ChEMBL_550664 (CHEMBL1002759)
IC50
73000±n/a nM
Citation
 Massiot, G; Long, C; David, B; Serrano, MJ; Daubié, F; Alby, F; Ausseil, F; Knibiehler, M; Moretti, C; Hoffmann, JS; Cazaux, C; Lavaud, C Acylphloroglucinol derivatives from Mahurea palustris. J Nat Prod 68:979-84 (2005) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM50241924
Synonyms:
CHEMBL486797 | Mahureone B
Type:
Small organic molecule
Emp. Form.:
C35H46O6
Mol. Mass.:
562.7361
SMILES:
[#6]-[#6]-[#6](-[#6])-[#6](=O)-[#6]-1-[#6](=O)-[#8]-[#6]2=[#6](-[#6](-[#6]-[#6](-[#8])=O)-c3ccccc3)C([#6])([#6])[#6](-[#6]\[#6]=[#6](\[#6])-[#6])-[#6]C2([#6]\[#6]=[#6](\[#6])-[#6])[#6]-1=O |c:10|
Structure:
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