Reaction Details Report a problem with these data
Target
ATP-dependent 6-phosphofructokinase
Ligand
BDBM50270348
Substrate
n/a
Meas. Tech.
ChEMBL_530309 (CHEMBL980371)
IC50
50000±n/a nM
Citation
Nowicki, MW; Tulloch, LB; Worralll, L; McNae, IW; Hannaert, V; Michels, PA; Fothergill-Gilmore, LA; Walkinshaw, MD; Turner, NJ Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. Bioorg Med Chem 16:5050-61 (2008) [PubMed] Article
More Info.:
Target
Name:
ATP-dependent 6-phosphofructokinase
Synonyms:
6-phospho-1-fructokinase | PFKA_TRYBB | pfk
Type:
PROTEIN
Mol. Mass.:
53537.94
Organism:
Trypanosoma brucei
Description:
ChEMBL_1288121
Residue:
487
Sequence:
MAVESRSRVTSKLVKAHRAMLNSVTQEDLKVDRLPGADYPNPSKKYSSRTEFRDKTDYIMYNPRPRDEPSSENPVSVSPLLCELAAARSRIHFNPTETTIGIVTCGGICPGLNDVIRSITLTGINVYNVKRVIGFRFGYWGLSKKGSQTAIELHRGRVTNIHHYGGTILGSSRGPQDPKEMVDTLERLGVNILFTVGGDGTQRGALVISQEAKRRGVDISVFGVPKTIDNDLSFSHRTFGFQTAVEKAVQAIRAAYAEAVSANYGVGVVKLMGRDSGFIAAQAAVASAQANICLVPENPISEQEVMSLLERRFCHSRSCVIIVAEGFGQDWGRGSGGYDASGNKKLIDIGVILTEKVKAFLKANKSRYPDSTVKYIDPSYMIRACPPSANDALFCATLATLAVHEAMAGATGCIIAMRHNNYILVPIKVATSVRRVLDLRGQLWRQVREITVDLGSDVRLARKLEIRRELEAINRNRDRLHEELAKL
Inhibitor
Name:
BDBM50270348
Synonyms:
(2S,3S,4S,5R)-5-((3,4-dichlorobenzylamino)methyl)-N-allyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide | CHEMBL477106
Type:
Small organic molecule
Emp. Form.:
C16H20Cl2N2O4
Mol. Mass.:
375.247
SMILES:
O[C@H]1[C@H](O)[C@H](O[C@@H]1CNCc1ccc(Cl)c(Cl)c1)C(=O)NCC=C |r|