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Target
Regulatory protein E2
Ligand
BDBM50035218
Substrate
n/a
Meas. Tech.
ChEMBL_532977 (CHEMBL989647)
Kd
>400000±n/a nM
Citation
 Saitoh, T; Kuramochi, K; Imai, T; Takata, K; Takehara, M; Kobayashi, S; Sakaguchi, K; Sugawara, F Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro. Bioorg Med Chem 16:5815-25 (2008) [PubMed]  Article 
Target
Name:
Regulatory protein E2
Synonyms:
E2 | VE2_HPV1
Type:
PROTEIN
Mol. Mass.:
45494.82
Organism:
Human papillomavirus type 1a
Description:
ChEMBL_532977
Residue:
401
Sequence:
MENLSSRLDLLQEQLMNLYEQDSKLIEDQIKQWNLIRQEQVLFHFARKNGVMRIGLQAVPSLASSQEKAKTAIEMVLHLESLKDSPYGTEDWSLQDTSRELFLAPPAGTFKKSGSTLEVTYDNNPDNQTRHTIWNHVYYQNGDDVWRKVSSGVDAVGVYYLEHDGYKNYYVLFAEEASKYSTTGQYAVNYRGKRFTNVMSSTSSPRAAGAPAVHSDYPTLSESDTAQQSTSIDYTELPGQGETSQVRQRQQKTPVRRRPYGRRRSRSPRGGGRREGESTPSRTPGSVPSARDVGSIHTTPQKGHSSRLRRLLQEAWDPPVVCVKGGANQLKCLRYRLKASTQVDFDSISTTWHWTDRKNTERIGSARMLVKFIDEAQREKFLERVALPRSVSVFLGQFNGS
  
Inhibitor
Name:
BDBM50035218
Synonyms:
CHEMBL61 | PODOFILOX | Podophyllinic acid lactone | Podophyllotoxin (PTOX) | podophyllotoxin
Type:
Small organic molecule
Emp. Form.:
C22H22O8
Mol. Mass.:
414.4053
SMILES:
COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12 |r|
Structure:
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