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Target
Beta-1 adrenergic receptor
Ligand
BDBM50241366
Substrate
n/a
Meas. Tech.
ChEMBL_514122 (CHEMBL968868)
Kd
0.380000±n/a nM
Citation
 Stephenson, KA; Wilson, AA; Meyer, JH; Houle, S; Vasdev, N Facile radiosynthesis of fluorine-18 labeled beta-blockers. Synthesis, radiolabeling, and ex vivo biodistribution of [18F]-(2S and 2R)-1-(1-fluoropropan-2-ylamino)-3-(m-tolyloxy)propan-2-ol. J Med Chem 51:5093-100 (2008) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50241366
Synonyms:
(S)-1-(isopropylamino)-3-(m-tolyloxy)propan-2-ol | (S)-1-(isopropylamino)-3-(m-tolyloxy)propan-2-ol ((2S)-toliprolol) | CHEMBL252319
Type:
Small organic molecule
Emp. Form.:
C13H21NO2
Mol. Mass.:
223.3113
SMILES:
CC(C)NC[C@H](O)COc1cccc(C)c1 |r|
Structure:
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