Reaction Details Report a problem with these data
Target
Leukotriene A-4 hydrolase
Ligand
BDBM50272144
Substrate
n/a
Meas. Tech.
ChEMBL_510221 (CHEMBL1004837)
IC50
2700±n/a nM
Citation
Enomoto, H; Morikawa, Y; Miyake, Y; Tsuji, F; Mizuchi, M; Suhara, H; Fujimura, K; Horiuchi, M; Ban, M Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett 18:4529-32 (2008) [PubMed] Article
More Info.:
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_CAVPO | LTA4H
Type:
PROTEIN
Mol. Mass.:
68972.78
Organism:
Cavia porcellus
Description:
ChEMBL_544515
Residue:
611
Sequence:
MPEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETESMLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHTWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGETQAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSITTDDWKNFLFSHFKDKVDILNQVDWDAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVTAMLVGKDLKVE
Inhibitor
Name:
BDBM50272144
Synonyms:
(2S,5S)-5-(3-(4-isopropylphenyl)propylthio)-1-((S)-3-mercapto-2-methylpropanoyl)pyrrolidine-2-carboxylic acid | CHEMBL499611
Type:
Small organic molecule
Emp. Form.:
C21H31NO3S2
Mol. Mass.:
409.606
SMILES:
CC(C)c1ccc(CCCS[C@H]2CC[C@H](N2C(=O)[C@H](C)CS)C(O)=O)cc1 |r|